Lab Members

Andrew Kruse

Principal Investigator

Andrew_Kruse@hms.harvard.edu

Research in my lab aims to elucidate the molecular basis of transmembrane signaling through the use of biochemistry, pharmacological studies, and structural biology. We are particularly interested in signaling pathways with connections to human health and disease, including G protein-coupled receptors and other transmembrane receptors. In the long term, we aim to leverage a detailed molecular understanding of these pathways to facilitate the development of new and better therapeutics.

PDF icon CV

Assaf Alon

Postdoctoral Fellow

Assaf_Alon@hms.harvard.edu

Assaf studied for his PhD at the Weizmann Institute of Science in Rehovot, Israel, under the supervision of Prof. Deborah Fass. His studies focused on elucidating the catalytic mechanism of the disulfide catalyst Quiescin-Sulfhydryl Oxidase (QSOX) by X-ray crystallography, FRET, and other biophysical methods. After receiving his PhD in 2012, Assaf joined the lab of Dr. Sarel Fleishman, also at the Weizmann, for a short postdoc aimed at switching species preference of antibodies using computational design. Assaf joined the Kruse lab in January 2016. Assaf is married and has two kids, a boy and a girl. In his free time he enjoys reading, cooking, and hiking with his family

Anthony Banks

Technician

Anthony_Banks@hms.harvard.edu

Anthony is from Ireland, where he received his Bachelor’s degree in experimental physics at University College Dublin. After moving to Chicago in 2009 he did a Master’s degree in applied physics at DePaul University, then 4 years as a biophysics research assistant at Florida State University. Anthony is married and he and his wife have two dogs. He has also worked as a painter, in the retail industry, in bars, and done door-to-door sales.  He enjoys sports, music, reading, swimming, and spending time with his wife.

Sarah Erlandson

Graduate Student

saraherlandson@g.harvard.edu

Sarah graduated from the University of South Carolina in 2015, where she studied the transcriptional and post-transcriptional regulation of the Wrap53 gene in the lab of Prof. David Reisman. After graduating from USC, she became a graduate student in the BBS program and joined the Kruse lab in 2016. 

Conor McMahon

Postdoctoral Fellow

Conor_McMahon@hms.harvard.edu

Conor received a Ph.D. from Princeton University under the advisement of Fred Hughson. While there, his work focused on characterizing trafficking proteins using structural and genetic methods. His research in the Kruse Lab focuses on engineering novel nanobodies for use as molecular tools and potential therapeutic agents.

Jaeho Paek

Graduate Student

jpaek@g.harvard.edu

Born in South Korea, Jaeho moved to the west coast to study chemistry and molecular & cell biology at UC Berkeley. As an undergraduate student, he worked on synthesizing fluorescent probes under the guidance of Prof. Christopher Chang. After four years in California, he decided to explore the East coast and is now a graduate student in the Chemical Biology program. As a member of the Kruse lab, he wants to gain expertise in biochemistry and structural biology.

Roberta Pascolutti

Postdoctoral Fellow

Roberta_Pascolutti@hms.harvard.edu

Roberta comes from Italy, she completed her Ph.D. in Milan under the supervision of  Prof. Pier Paolo Di Fiore, with whom she studied the molecular mechanism of EGFR internalization. In May 2014 she joined Prof. Kirchhausen lab for a collaborative project and then she came back to Boston as a postdoctoral researcher to join the Kruse lab. Her main goal is to gain a strong structural biology background. In her spare time she likes travelling, swimming and cooking.

Hayden Schmidt

Graduate Student

haydenschmidt@g.harvard.edu

Hayden recieved his bachelor's degree from Whittier College in 2014, where he worked with Dr. Erica Fradinger on a zebrafish model for organophosphate antidotes. He joined the Kruse lab in 2015, and currently works on the structure and function of sigma receptors. 

Megan Sjodt

Postdoctoral Fellow

megan_sjodt@hms.harvard.edu

Megan received her Ph.D. in Biochemistry and Molecular Biology from UCLA under the advisement of Prof. Robert Clubb. Her studies focused on investigating the molecular mechanism of hemoglobin capture and heme acquisition by Staphylococcus aureus using NMR spectroscopy, stopped-flow kinetics, and other biophysical methods. She joined the Kruse lab in September 2016. In her spare time, Megan likes to cook, read, and explore the city.

Katherine Susa

Graduate Student

ksusa@g.harvard.edu

Katherine graduated from Williams College in 2015 with a B.A. in Chemistry. At Williams, she conducted research on a stress response sigma factor in Streptomyces coelicolor. After graduating, she moved to the Bay Area to work at a biotech company, and then moved back to the east coast to become a student in the Chemical Biology program. She joined the Kruse Lab in 2017 and is jointly mentored by Steve Blacklow.

Sanduo Zheng

Postdoctoral Fellow

Sanduo_Zheng@hms.harvard.edu

Sanduo graduated from National Institute of Biological Science, Beijing in June 2013 with a Ph.D. degree in structural biology. During his Ph.D., he studied protein complexes involved in ribosome biogenesis and gene dosage compensation using NMR spectroscopy, X-ray crystallography, as well as biochemical and genetic methods. He joined the Kruse lab as a postdoctoral fellow in May 2015.