Research in my lab aims to elucidate the molecular basis of transmembrane signaling through the use of biochemistry, pharmacological studies, and structural biology. We are particularly interested in signaling pathways with connections to human health and disease, including G protein-coupled receptors and other transmembrane receptors. In the long term, we aim to leverage a detailed molecular understanding of these pathways to facilitate the development of new and better therapeutics.
Originally from Delaware, Claire received her B.S. in Molecular and Cellular Biology from the University of Maine. As a part of the Honors College, she wrote an undergraduate thesis focused on the intrinsic antibiotic resistance of mycobacteria, specifically focusing on the membrane protein flotillin. She joined the Kruse lab in May 2023 where she works primarily with the bacterial subgroup. Her hobbies include rating movies and books, as well as trying to keep her two cats from destroying her apartment while she's at work.
Victor received his B.S. in Microbiology with a minor in Biochemistry from the University in Arizona where he worked under the supervision of Dr. May Khanna in identifying small molecule modulators of TDP43 and Malat1, both implicated in neurodegenerative diseases, using in silico docking and biophysical binding assays. After graduating from the UA, Victor joined the Chemical Biology program in 2020 and joined the Kruse lab in 2021. In his spare time, he enjoys spending time with his partner and dogs, playing chess, and spending time at the beach.
Josh (B.S., Molecular Biophysics & Biochemistry, Yale, 2015; Ph.D., Molecular & Cell Biology, UC Berkeley, 2021) completed his doctoral work in the labs of Jennifer Doudna and John Kuriyan, where he studied how protein and nucleic acid conformational dynamics enable the function of CRISPR-associated enzymes in bacterial immunity and genome editing applications. In 2022, he began his postdoc in the Kruse lab, where he is using biochemistry and structural biology to probe bacterial membrane protein function. Outside of lab, Josh likes Baroque music, climbing on real and fake rocks, and sleeping in tents.
Morgan received her Ph.D. in Biochemistry and Cell Biology from Dartmouth College under the supervision of Dr. Jason McLellan. Her thesis research centered on determining the molecular mechanisms of the interactions between viral fusion glycoproteins and the host humoral immune system, with a primary focus on respiratory syncytial virus (RSV). She joined the Kruse lab in August 2019.
Jinghan received her Ph.D. in Medicinal Chemistry at the University of Michigan in Dr. Emily Scott’s lab. Her thesis research focused on the structure and function of cytochrome P450 enzymes to support drug design for major human diseases and drug metabolism predictions in neonates. She joined the Kruse lab in September 2023.
James received his Ph.D. in Cellular and Molecular Physiology from Johns Hopkins School of
Medicine under the supervision of Dr. Zhaozhu Qiu. His thesis work focused on structure-
function characterization of a novel proton-activated chloride channel (PAC). James likes to hike
and play soccer in his spare time. He joined the Kruse Lab in November 2021.
Daniel was born in Cuba but grew up in the suburbs of Philadelphia. As an undergraduate at Princeton University, he worked in the laboratory of Thomas Silhavy to characterize the role of YejM in regulating LPS biosynthesis. After graduating in 2020 with a B.S. in molecular biology, he became a research assistant in the laboratory of Cigall Kadoch at Dana Farber Cancer Institute. Here, he studied the function of mSWI/SNF (BAF) chromatin remodeling complexes in normal and oncogenic cell states. He then joined the Chemical Biology program in 2022, and the Kruse and Loparo laboratories in 2023. Daniel's current research is focused on understanding the regulatory mechanisms of protein complexes that build the bacterial cell wall. In his free time, he enjoys cycling, running, hiking, and trying different espresso beans.
Jeffrey is from Washington State, attending the University of Washington for undergraduate. There he joined the laboratory of Charles Chavkin, studying opioid pharmacology. He subsequently matriculated in Duke University’s MD/PhD program, studying chemokine receptor signaling and biased agonism under the mentorship of Sudar Rajagopal and Robert Lefkowitz. After completing a medicine intern year, Jeffrey completed residency in the Harvard Combined Dermatology Residency Program. He joined the Kruse Lab in 2022 and is studying noncanonical GPCR signaling. He is also an attending at the Brigham and Women’s Hospital where he cares for patients with autoimmune skin diseases.