Kruse AC publications on PubMed


Dates AN, Jones DTD, Smith JS, Skiba MA, Rich MF, Burruss MM, Kruse AC, Blacklow SC.
Cell Chem Biol. 2024 Apr 4:S2451-9456(24)00120-X
Heterogeneity of tethered agonist signaling in adhesion G protein-coupled recep…
Smith JS, Hilibrand AS, Skiba MA, Dates AN, Calvillo-Miranda VG, Kruse AC.
Mol Pharmacol. 2024 Apr 19:MOLPHARM-AR-2023-000818
The M3 muscarinic acetylcholine receptor can signal through multiple G protein …
Gao Y, Amon JD, Brogan AP, Artzi L, Ramírez-Guadiana FH, Cofsky JC, Kruse AC, Rudner DZ.
Genes Dev. 2024 Feb 13;38(1-2):31-45
SpoVAF and FigP assemble into oligomeric ion channels that enhance spore germin…
Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D.
Nature. 2024 Jan;625(7996):E27
Author Correction: A new antibiotic traps lipopolysaccharide in its intermembra…
Pahil KS, Gilman MSA, Baidin V, Clairfeuille T, Mattei P, Bieniossek C, Dey F, Muri D, Baettig R, Lobritz M, Bradley K, Kruse AC, Kahne D.
Nature. 2024 Jan;625(7995):572-577
A new antibiotic traps lipopolysaccharide in its intermembrane transporter


Susa KJ, Kruse AC, Blacklow SC.
Trends Cell Biol. 2023 Sep 30:S0962-8924(23)00195-2
Tetraspanins: structure, dynamics, and principles of partner-protein recognitio…
Shlosman I, Fivenson EM, Gilman MSA, Sisley TA, Walker S, Bernhardt TG, Kruse AC, Loparo JJ.
Nat Commun. 2023 Jun 10;14(1):3439
Allosteric activation of cell wall synthesis during bacterial growth
Gao Y, Amon JD, Artzi L, Ramírez-Guadiana FH, Brock KP, Cofsky JC, Marks DS, Kruse AC, Rudner DZ.
Science. 2023 Apr 28;380(6643):387-391
Bacterial spore germination receptors are nutrient-gated ion channels
Erlandson SC, Rawson S, Osei-Owusu J, Brock KP, Liu X, Paulo JA, Mintseris J, Gygi SP, Marks DS, Cong X, Kruse AC.
Nat Chem Biol. 2023 Aug;19(8):1013-1021
The relaxin receptor RXFP1 signals through a mechanism of autoinhibition


Harvey EP, Shin JE, Skiba MA, Nemeth GR, Hurley JD, Wellner A, Shaw AY, Miranda VG, Min JK, Liu CC, Marks DS, Kruse AC.
Nat Commun. 2022 Dec 7;13(1):7554
An in silico method to assess antibody fragment polyreactivity.
Li Q, Humphries F, Girardin RC, Wallace A, Ejemel M, Amcheslavsky A, McMahon CT, Schiller ZA, Ma Z, Cruz J, Dupuis AP, Payne AF, Maryam A, Yilmaz NK, McDonough KA, Pierce BG, Schiffer CA, Kruse AC, Klempner MS, Cavacini LA, Fitzgerald KA, Wang Y.
Front Immunol. 2022 Sep 12;13:995412
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic t…
Page JE, Skiba MA, Do T, Kruse AC, Walker S.
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26)
Metal cofactor stabilization by a partner protein is a widespread strategy empl…
Gao Y, Barajas-Ornelas RDC, Amon JD, Ramírez-Guadiana FH, Alon A, Brock KP, Marks DS, Kruse AC, Rudner DZ.
Genes Dev. 2022 May 1;36(9-10):634-646
The SpoVA membrane complex is required for dipicolinic acid import during sporu…


Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. Structures of the σ2 receptor enable docking for bioactive ligand discovery. Nature. 2021 Dec;600(7890):759-764
Structures of the σ2 receptor enable docking for bioactive ligand discovery.
Tummino TA, Rezelj VV, Fischer B, Fischer A, O'Meara MJ, Monel B, Vallet T, White KM, Zhang Z, Alon A, Schadt H, O'Donnell HR, Lyu J, Rosales R, McGovern BL, Rathnasinghe R, Jangra S, Schotsaert M, Galarneau JR, Krogan NJ, Urban L, Shokat KM, Kruse AC, García-Sastre A, Schwartz O, Moretti F, Vignuzzi M, Pognan F, Shoichet BK. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2. Science. 2021 Jul 30;373(6554):541-547
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2.
Wellner A, McMahon C, Gilman MSA, Clements JR, Clark S, Nguyen KM, Ho MH, Hu VJ, Shin JE, Feldman J, Hauser BM, Caradonna TM, Wingler LM, Schmidt AG, Marks DS, Abraham J, Kruse AC, Liu CC. Rapid generation of potent antibodies by autonomous hypermutation in yeast. Nat Chem Biol. 2021 Oct;17(10):1057-1064
Rapid generation of potent antibodies by autonomous hypermutation in yeast.
Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS. Protein design and variant prediction using autoregressive generative models. Nat Commun. 2021 Apr 23;12(1):2403
Protein design and variant prediction using autoregressive generative models.
Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO. COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms. Front Pharmacol. 2021 Mar 23;12:633680.
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.
Susa KJ, Rawson S, Kruse AC*, Blacklow SC*. Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81. (2021) Science 371, 300-305. *Corresponding authors.
Skiba MA, Kruse AC. Autoantibodies as Endogenous Modulators of GPCR Signaling. (2021) Trends. Pharmacol. Sci. 42, 135-150.
Amcheslavsky A, Wallace AL, Ejemel M, Li Q, McMahon CT, Stoppato M, Giuntini S, Schiller ZA, Pondish JR, Toomey JR, Schneider RM, Meisinger J, Heukers R, Kruse AC, Barry EM, Pierce BG, Klempner MS, Cavacini LA, Wang Y. Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design. (2021) Sci. Rep. 11, 2751.


Greenfield DA, Schmidt HR, Skiba MA, Mandler MD, Anderson JR, Sliz P, Kruse AC.
Virtual Screening for Ligand Discovery at the σ1 Receptor.
ACS Med Chem Lett. 2020 Jul 27;11(8):1555-1561
Virtual Screening for Ligand Discovery at the σ1 Receptor.
McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers.
Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20284-20291 Synthetic nanobodies as angiotensin receptor blockers.
Susa KJ, Seegar TC, Blacklow SC*, Kruse AC*. A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. (2020) eLife, 9:e52337. *Corresponding authors.
Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC. Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. (2020) Nat. Microbiol., 5, 813-820.
Yu C, Wang L, Rowe RG, Han A, Ji W, McMahon C, Baier AS, Huang YC, Marion W, Pearson DS, Kruse AC, Daley GQ, Wu H, Sliz P. A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7. (2020) Proc. Natl. Acad. Sci. U. S. A. 117, 4653-4663.
Suomivuori CM, Lotorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. (2020) Science 367, 881-887.
Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz LW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ*, Kruse AC*. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. (2020) Science 367, 888-892. *Corresponding authors.
Pascolutti R, Erlandson SC, Burri DJ, Zheng S, Kruse AC. Mapping and engineering the interaction between adiponectin and T-cadherin. (2020) J. Biol. Chem. 295, 2749-2759.


Schmidt HR, Kruse AC. The molecular function of sigma receptors: past, present, and future. (2019) Trends Pharmacol. Sci. 40, 636-654.
Chen H, Nwe P, Yang Y, Rosen CE, Bielecka AA, Kuchroo M, Cline GW, Kruse AC, Ring AM, Crawford JM, Palm NW. A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology. (2019) Cell 177, 1217-1231.
Owens T, Taylor R, Pahil K, Bertani B, Ruiz N*, Kruse AC*, Kahne D*. Structural basis for unidirectional export of lipopolysaccharide to the cell surface. (2019) Nature 567, 550-553. *Corresponding authors
Zheng S, Abreu N, Levitz J, Kruse AC. Structural basis for KCTD-mediated rapid desensitization of GABA-B signaling. (2019) Nature 567, 127-131.
Taguchi A, Welsh MA, Marmont LS, Lee W, Sjodt M, Kruse AC, Kahne D, Bernhardt TG, Walker S. FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein. (2019) Nat. Microbiol. 4, 587-594.
Zheng S, Kruse AC. Solving a specificity mystery. (2019) eLife e44298. (Commentary)
Wingler LM*, McMahon C*, Staus DP*, Lefkowitz RJ, Kruse AC. Structure of active-state angiotensin receptor stabilized by a synthetic nanobody. (2019) Cell 76, 479-490. *Equal contributors


Ramírez-Guadiana FH, Rodrigues CDA, Marquis KA, Campo N, Barajas-Ornelas R, Brock K, Marks DS, Kruse AC, Rudner DZ. Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis. (2018) PLoS Genet. 14(11):e1007753
Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. (2018) PLoS Genet. 14(10):e1007726.
Schmidt HR, Betz RM, Dror RO, Kruse AC. Structural basis for σ1 receptor ligand recognition. (2018) Nat. Struct. Mol. Biol. 25, 981-987.
Wang X, Hughes AC, Brandão HB, Walker B, Lierz C, Cochran JC, Oakley MG, Kruse AC, Rudner DZ. In Vivo Evidence for ATPase-Dependent DNA Translocation by the Bacillus subtilis SMC Condensin Complex. (2018) Mol. Cell S1097-2765(18)30553-7
Sham LT, Zheng S, Yakhnina AA, Kruse AC, Bernhardt TG. Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP-family flippases. (2018) Mol. Microbiol. 109, 633-641.
Zheng S, Sham LT, Rubino FA, Brock KP, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. Structure and mutagenic analysis of the lipid II flippase MurJ from Escherichia coli. (2018) Proc. Natl. Acad. Sci. U.S.A. 115, 6709-6714.
Huang P, Zheng S, Wierbowski BM, Kim Y, Nedelcu D, Aravena L, Liu J, Kruse AC, Salic A. Structural Basis of Smoothened Activation in Hedgehog Signaling. (2018) Cell. 174, 312-324.
Linkens K, Schmidt HR, Sahn JJ, Kruse AC, Martin SF. Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties. (2018) Eur. J. Med. Chem. 151, 557-567.
Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. (2018) Nature 556, 118-121.
Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. (2018) Proc. Natl. Acad. Sci. U.S.A. 115, 3834-3839. Abstract
Erlandson SC, McMahon C, Kruse AC. Structural Basis for G Protein-Coupled Receptor Signaling. (2018) Annu. Rev. Biophys. Epub ahead of print.
Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK. Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor. (2018) Proc. Natl. Acad. Sci. U.S.A. 6;115(10):E2419-E2428.
McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A*, Kruse AC*. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. (2018) Nat. Struct. Mol. Biol. 25(3):289-296. *Corresponding authors


Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. (2017) Cell 171, 1638-1648.
Manglik A*, Kruse AC*. Structural basis for G protein-coupled receptor activation. (2017) Biochemistry. Online ahead of print. *Co-corresponding.
Ramírez-Guadiana FH, Meeske AJ, Rodrigues CDA, Barajas-Ornelas RDC, Kruse AC, Rudner DZ. A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis. (2017) PLoS Genet. 13, e1007015.
Alon A*, Schmidt HR*, Wood MD*, Sahn JJ, Martin SF, Kruse AC. Identification of the gene that codes for the sigma-2 receptor. (2017) Proc. Natl. Acad. Sci. U.S.A. 114, 7160-7165. *Equal contributors
Sguazzini E, Schmidt HR, Iyer KA, Kruse AC, Dukat M. Reevaluation of fenpropimorph as a sigma receptor ligand: Structure-affinity relationship studies at human sigma-1 receptors. (2017) Bioorg. Med. Chem. Lett. 27, 2912-2919.
Paek J*, Kalocsay M*, Staus DP, Wingler L, Pascolutti R, Paulo JA, Gygi SP, Kruse AC. Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling. (2017) Cell 169, 338-349. *Equal contributors. Cell
Alon A, Schmidt HR, Zheng S, Kruse AC. Structural Perspectives on sigma-1 receptor function. (2017) in Sylvia Smith et al. (Eds.), Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Adv. Exp. Med. Biol., Vol. 964. Abstract
Kruse AC. (2017) Structural insights into sigma1 function. Handb. Exp. Pharmacol. Abstract


Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC*, Blacklow SC*. Crystal structure of a full-length human tetraspanin reveals a cholesterol binding pocket. (2016) Cell 167, 1041-1051. *Co-corresponding Abstract
Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC. Structure and dynamics of PD-L1 and an ultra high-affinity PD-1 receptor mutant. (2016) Structure 24, 1719-1728. Abstract
Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. (2016) Nature 537, 634-638. Abstract
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. (2016) Nature 535, 448-452. Abstract
Schmidt HR*, Zheng S*, Gurpinar E, Koehl A, Manglik A, Kruse AC. Crystal structure of the human sigma-1 receptor (2016) Nature 532, 527-530. *Equal contributors Abstract
Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Christopher Fromme J, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. (2016) Nat. Commun. 7, 10882 Abstract
Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. High-density grids for efficient data collection from multiple crystals. (2016) Acta Crystallogr. D72, 2-11. Abstract


Li Q, Tachie-Baffour Y, Liu Z, Baldwin MW, Kruse AC, Liberles SD. Non-classical amine recognition evolved in a large clade of olfactory receptors. (2015) eLife, 4:e10441. Abstract
Maute RL, Gordon SR, Mayer AT, McCracken MN, Natarajan A, Ring NG, Kimura R, Tsai JM, Manglik A, Kruse AC, Gambhir SS, Weissman IL, Ring AM. Engineering high-affinity PD-1 variants for optimized immunotherapy and immune-PET imaging. (2015) Proc. Natl. Acad. Sci. USA, 112, E6506-E6514. Abstract


Cohen AE, Soltis SM, González A, Aguila L, Alonso-Mori R, Barnes CO, Baxter EL, Brehmer W, Brewster AS, Brunger AT, Calero G, Chang JF, Chollet M, Ehrensberger P, Eriksson TL, Feng Y, Hattne J, Hedman B, Hollenbeck M, Holton JM, Keable S, Kobilka BK, Kovaleva EG, Kruse AC, Lemke HT, Lin G, Lyubimov AY, Manglik A, Mathews II, McPhillips SE, Nelson S, Peters JW, Sauter NK, Smith CA, Song J, Stevenson HP, Tsai Y, Uervirojnangkoorn M, Vinetsky V, Wakatsuki S, Weis WI, Zadvornyy OA, Zeldin OB, Zhu D, Hodgson KO. Goniometer-based femtosecond crystallography with X-ray free electron lasers. (2014) Proc. Natl. Acad. Sci. USA, 111, 17122-17127. Abstract
Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. (2014) Nat. Rev. Drug Discov., 13, 549-560. Abstract
Kruse AC*, Hu J, Kobilka BK, Wess J*. Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. (2014) Curr. Opin. Pharmacol. 16C, 24-30.
*Corresponding Abstract
Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Covalent neurotransmitter surrogates for the structural investigation of aminergic G protein-coupled receptors. (2014) Proc. Natl. Acad. Sci. USA 111, 10744-10748. Abstract


Kruse AC*, Ring AM*, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, Wess J, Kobilka BK. Activation and allosteric modulation of a muscarinic acetylcholine receptor. (2013) Nature 504, 101-106. *Equal contributors Abstract
Kruse AC, Li J, Hu J, Kobilka BK, Wess J. Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. (2013) J. Mol. Neurosci. 53, 316 - 323. Abstract
Kruse AC, Manglik A, Kobilka BK, Weis WI. Applications of molecular replacement to G protein-coupled receptors. (2013) Acta Cryst. D69, 2287-2292. Abstract
Kruse AC*, Weiss DR*, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK. Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. (2013) Mol. Pharm. 84, 528-540. *Equal contributors Abstract
Ring AM*, Manglik A*, Kruse AC*, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of the β2-adrenoceptor stabilized by an engineered nanobody. (2013) Nature 502, 575-579. *Equal contributors Abstract
Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Novel Tripod Amphiphiles for Membrane Protein Analysis. (2013) Chem. Eur. J. 19, 15645-15651. Abstract
Shukla AK*, Manglik A*, Kruse AC*, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. (2013) Nature 497, 137-141. *Equal contributors Abstract
Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka BK, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH. Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study. (2013) Chem. Commun. 49, 2287-2289. Abstract


Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. (2012) Nature 482, 552-556. Abstract
Haga K*, Kruse AC*, Asada H*, Yurugi-Kobayashi T, Shiroishi M, Zhang C, Weis WI, Okada T, Kobilka BK, Haga T, Kobayashi T. Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. (2012) Nature 482, 547-551. *Equal contributors Abstract
Granier S, Manglik A*, Kruse AC*, Kobilka TS, Thian FS, Weis WI, Kobilka BK. Crystal structure of the δ-opioid receptor bound to naltrindole. (2012) Nature 485, 400-404. *Equal contributors Abstract
Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S. Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. (2012) Nature 485, 321-326. Abstract
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. (2012) Chem. Eur. J. 18, 9485-9490. Abstract


Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC. T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. (2011) Immunity 35, 681-693. Abstract
Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK. Crystal structure of the β2 adrenergic receptor-Gs protein complex. (2011) Nature 477, 549-555. Abstract
Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin A, Kuhns MS, Garcia KC, Davis MM. Structural insight into the Specificity and Cross Reactivity of T Cell Receptors specific for Cytochrome c-I-Ek. (2011) J. Immunol. 186, 5823-5832. Abstract
Kruse AC, Huseby M, Shi K, Digre J, Ohlendorf DH, Earhart CA. Structure of a mutant beta toxin from Staphylococcus aureus reveals domain swapping and conformational flexibility. (2011) Acta Cryst. F67, 438-441. Abstract


Chae PS, Rasmussen SGF, Rana R, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, Gether U, Byrne B, Kobilka B, Gellman SH. Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. (2010) Nat. Methods 7, 1003-1008. Abstract
Chu HH, Moon JJ, Kruse AC, Pepper M, Jenkins MK. Negative Selection and Peptide Chemistry Determine the Size of Naive Foreign Peptide-MHC Class II-Specific CD4+ T Cell Populations. (2010) J. Immunol. 185, 4705-4713. Abstract
Huseby M, Kruse AC, Digre J, Mann EE, Bayles KW, Bohach GA, Schlievert PM, Ohlendorf DH, Earhart CA. Beta-toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms. (2010) Proc. Natl. Acad. Sci. U. S. A. 107, 14407-14412. Abstract
Hellberg K, Grimsrud PA, Kruse AC, Banaszak LJ, Ohlendorf DH, Bernlohr DA. X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal. (2010) Protein Sci. 19, 1480-1489. Abstract


Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA. Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins. (2009) J. Med. Chem. 52, 6024-6031. Abstract


Yoder AR, Kruse AC, Earhart CA, Ohlendorf DH, Potter LR. Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice. (2008) Peptides. 29, 1575-1581. Abstract